America's Most Wanted: Missing Persons is an all-new format that centers on finding missing people and reuniting them with their families. Each week, a panel composed of esteemed crime experts will dive deep into analyzing various missing person cases, and multiple panelists will travel on-location for a field investigation, in hopes of gaining additional insight of the case under discussion. Faulkner and the expert panelists will further urge fellow viewers to participate as armchair detectives by providing tips to help law enforcement find missing individuals and bring closure to families.